GxPlex

An independent, dated record of what regulators published, and when it changed

Every tracked document is fetched, normalised and hashed on a daily schedule. The hash is recorded whether or not anything changed — because "unchanged for 412 days" is only a fact if all 412 observations exist.

The archive
Days of continuous observation Instruments Observations recorded Revisions detected Silent revisions
0 0 0 0 0

A silent revision is a document whose content changed with no version or date declared alongside it. Detecting one requires having hashed the document before it changed. Since .

Detected revisions · Findings, each with its method · Which sources are machine-readable · Snapshots and hashes · How this is done

What this is not

It reports what documents say and when they changed. It contains no interpretation, no recommendations, and no assessment of what any document requires of any organisation. Read the primary source and take your own professional advice.

Current status of tracked instruments

A view of the archive, not the product. Status is recorded only after a person has checked it against the primary source.

35 of 35 statuses are not yet verified. They are listed so coverage is visible. Observation of those documents is already running — verification and observation are independent.

EU (11)

EU instruments
Instrument Authority Status Last changed Last verified Source
EASA AI European Union Aviation Safety Agency not yet verified link
EMA QIG European Medicines Agency not yet verified link
EU AI Act European Parliament and Council not yet verified link
EU GMP Annex 11 European Commission not yet verified link
EU GMP Annex 22 European Commission not yet verified link
EU IVDR European Parliament and Council not yet verified link
EU MDR European Parliament and Council not yet verified link
prEN 18229-1 CEN/CENELEC JTC 21 not yet verified link
prEN 18229-2 CEN/CENELEC JTC 21 not yet verified link
prEN 18281 CEN/CENELEC JTC 21 not yet verified link
prEN 18282 CEN/CENELEC JTC 21 not yet verified link

US (6)

US instruments
Instrument Authority Status Last changed Last verified Source
21 CFR Part 11 US Food and Drug Administration not yet verified link
FDA AI guidance US Food and Drug Administration not yet verified link
FDA CDRH AI/ML US Food and Drug Administration not yet verified link
FDA CSA US Food and Drug Administration not yet verified link
FDA ETP US Food and Drug Administration not yet verified link
FDA guidance agenda US Food and Drug Administration not yet verified link

International (13)

International instruments
Instrument Authority Status Last changed Last verified Source
GAMP 5 2nd Ed ISPE not yet verified link
GAMP AI Guide ISPE not yet verified link
ICH Q12 International Council for Harmonisation not yet verified link
ICH Q13 International Council for Harmonisation not yet verified link
ICH Q14 International Council for Harmonisation not yet verified link
ICH Q2(R2) International Council for Harmonisation not yet verified link
ICH Q9(R1) International Council for Harmonisation not yet verified link
IMDRF SaMD International Medical Device Regulators Forum not yet verified link
ISO/IEC 23894 ISO/IEC not yet verified link
ISO/IEC 42001 ISO/IEC not yet verified link
NIST AI RMF US National Institute of Standards and Technology not yet verified link
PIC/S GMP Guide Pharmaceutical Inspection Co-operation Scheme not yet verified link
UNECE WP.29 United Nations Economic Commission for Europe not yet verified link

UK (1)

UK instruments
Instrument Authority Status Last changed Last verified Source
MHRA AI Medicines and Healthcare products Regulatory Agency not yet verified link

Other (4)

Other instruments
Instrument Authority Status Last changed Last verified Source
Health Canada ML Health Canada not yet verified link
PMDA AI Pharmaceuticals and Medical Devices Agency not yet verified link
Swissmedic Swissmedic not yet verified link
TGA SaMD Therapeutic Goods Administration not yet verified link

Machine-readable

/api/observations.json · /api/revisions.json · /api/findings.json · /api/crawlability.json · /api/instruments.json · RSS

Last updated: